Study of Cancer Genes in X -chromosome

Cancer results due to mutations that occur within our genetic material. A small proportion of our genes are directly involved in maintaining normal cell growth; mutations that occur within these genes can eventually lead to cancer. Stevenson et al. was the first to discover the various reasons for the occurrence and the prevalence of cancer with the X-Chromosomal disorders. Our research focused on finding out the cancerous genes located on X – chromosome and the study of their expression. We found in majority were in the tissues of nervous systems, liver, pancreas and prostate which is characteristics of higher mammalians. Hence the sex chromosomes play a major role in cancer. Another important conclusion we were able to draw from the analysis is that CT antigens and its homologs were found to be most important in cancer and hence we investigated on MAGEE1 the most important CT antigens, which was found to be more responsible for causing cancer, Several databases were made use of in the comprehensive analysis of the magee1 gene. An extensive analysis of the magee1 gene including modeling of its structure may prove useful in designing a drug for cancer treatment.